Diacylglycerol Kinase Limits the Generation of Natural Regulatory T Cells
نویسندگان
چکیده
منابع مشابه
Diacylglycerol Kinase ζ Limits Cytokine-dependent Expansion of CD8+ T Cells with Broad Antitumor Capacity
Interleukin-2 and -15 drive expansion/differentiation of cytotoxic CD8+ T cells that eliminate targets via antigen-independent killing. This property is clinically relevant for the improvement of T cell-based antitumor therapies. Diacylglycerol kinase α and ζ (DGKα/ζ) metabolize the diacylglycerol generated following antigen recognition by T lymphocytes. Enhanced expression of these two lipid k...
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ژورنال
عنوان ژورنال: Science Signaling
سال: 2013
ISSN: 1945-0877,1937-9145
DOI: 10.1126/scisignal.2004411